SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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Browse biological pathways impacted by somatic mutations in miRNA target sites: Experimental |
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Table: Cancer and other human diseases | ||
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Pathway ID | Pathway Class | Description | Number of Genes with Somatic mutation |
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Cancers: Overview | Pathways in cancer | 158 | |
Cancers: Specific types | Basal cell carcinoma | 29 | |
Cancers: Specific types | Renal cell carcinoma | 33 | |
Cancers: Specific types | Colorectal cancer | 33 | |
Cancers: Specific types | Pancreatic cancer | 35 | |
Cancers: Specific types | Endometrial cancer | 31 | |
Cancers: Specific types | Glioma | 33 | |
Cancers: Specific types | Prostate cancer | 45 | |
Cancers: Specific types | Thyroid cancer | 11 | |
Cancers: Specific types | Melanoma | 33 | |
Cancers: Specific types | Bladder cancer | 20 | |
Cancers: Specific types | Chronic myeloid leukemia | 37 | |
Cancers: Specific types | Acute myeloid leukemia | 30 | |
Cancers: Specific types | Small cell lung cancer | 45 | |
Cancers: Specific types | Non-small cell lung cancer | 33 | |
Cardiovascular diseases | Viral myocarditis | 29 | |
Cardiovascular diseases | Hypertrophic cardiomyopathy (HCM) | 33 | |
Cardiovascular diseases | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 34 | |
Endocrine and metabolic diseases | Type II diabetes mellitus | 20 | |
Endocrine and metabolic diseases | Type I diabetes mellitus | 16 | |
Endocrine and metabolic diseases | Maturity onset diabetes of the young | 5 | |
Immune diseases | Primary immunodeficiency | 11 | |
Immune diseases | Graft-versus-host disease | 14 | |
Immune diseases | Allograft rejection | 13 | |
Immune diseases | Systemic lupus erythematosus | 65 | |
Immune diseases | Autoimmune thyroid disease | 15 | |
Immune diseases | Asthma | 8 | |
Infectious diseases: Bacterial | Shigellosis | 20 | |
Infectious diseases: Bacterial | Bacterial invasion of epithelial cells | 25 | |
Infectious diseases: Bacterial | Vibrio cholerae infection | 14 | |
Infectious diseases: Bacterial | Epithelial cell signaling in Helicobacter pylori infection | 19 | |
Infectious diseases: Bacterial | Pathogenic Escherichia coli infection | 15 | |
Infectious diseases: Parasitic | Leishmaniasis | 30 | |
Neurodegenerative diseases | Parkinson's disease | 35 | |
Neurodegenerative diseases | Alzheimer's disease | 50 | |
Neurodegenerative diseases | Amyotrophic lateral sclerosis (ALS) | 22 | |
Neurodegenerative diseases | Huntington's disease | 58 | |
Neurodegenerative diseases | Prion diseases | 16 |
Table: Cellular Processes | ||
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Pathway ID | Pathway Class | Description | Number of Genes with Somatic mutation |
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Cell growth and death | Cell cycle | 55 | |
Cell growth and death | Oocyte meiosis | 43 | |
Cell growth and death | p53 signaling pathway | 27 | |
Transport and catabolism | Regulation of autophagy | 10 | |
Transport and catabolism | Lysosome | 47 | |
Transport and catabolism | Endocytosis | 88 | |
Transport and catabolism | Peroxisome | 32 | |
Cell growth and death | Apoptosis | 37 | |
Cell communication | Focal adhesion | 78 | |
Cell communication | Adherens junction | 34 | |
Cell communication | Tight junction | 54 | |
Cell communication | Gap junction | 41 | |
Cell motility | Regulation of actin cytoskeleton | 75 |
Table: Environmental Information Processing | ||
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Pathway ID | Pathway Class | Description | Number of Genes with Somatic mutation |
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Membrane transport | ABC transporters | 19 | |
Signal transduction | MAPK signaling pathway | 112 | |
Signal transduction | ErbB signaling pathway | 41 | |
Signal transduction | Calcium signaling pathway | 59 | |
Signaling molecules and interaction | Cytokine-cytokine receptor interaction | 68 | |
Signal transduction | Phosphatidylinositol signaling system | 34 | |
Signaling molecules and interaction | Neuroactive ligand-receptor interaction | 78 | |
Signal transduction | mTOR signaling pathway | 21 | |
Signal transduction | Wnt signaling pathway | 69 | |
Signal transduction | Notch signaling pathway | 19 | |
Signal transduction | Hedgehog signaling pathway | 29 | |
Signal transduction | TGF-beta signaling pathway | 38 | |
Signal transduction | VEGF signaling pathway | 31 | |
Signaling molecules and interaction | ECM-receptor interaction | 32 | |
Signaling molecules and interaction | Cell adhesion molecules (CAMs) | 42 | |
Signal transduction | Jak-STAT signaling pathway | 41 |
Table: Genetic Information Processing | ||
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Pathway ID | Pathway Class | Description | Number of Genes with Somatic mutation |
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Translation | Aminoacyl-tRNA biosynthesis | 16 | |
Translation | Ribosome | 17 | |
Folding, sorting and degradation | RNA degradation | 21 | |
Transcription | RNA polymerase | 7 | |
Transcription | Basal transcription factors | 13 | |
Replication and repair | DNA replication | 7 | |
Transcription | Spliceosome | 67 | |
Folding, sorting and degradation | Proteasome | 16 | |
Folding, sorting and degradation | Protein export | 8 | |
Replication and repair | Base excision repair | 11 | |
Replication and repair | Nucleotide excision repair | 11 | |
Replication and repair | Mismatch repair | 6 | |
Replication and repair | Homologous recombination | 8 | |
Replication and repair | Non-homologous end-joining | 7 | |
Folding, sorting and degradation | Ubiquitin mediated proteolysis | 58 | |
Folding, sorting and degradation | SNARE interactions in vesicular transport | 16 |
Table: Metabolism | ||
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Pathway ID | Pathway Class | Description | Number of Genes with Somatic mutation |
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Carbohydrate metabolism | Glycolysis / Gluconeogenesis | 15 | |
Carbohydrate metabolism | Citrate cycle (TCA cycle) | 5 | |
Carbohydrate metabolism | Pentose phosphate pathway | 8 | |
Carbohydrate metabolism | Pentose and glucuronate interconversions | 2 | |
Carbohydrate metabolism | Fructose and mannose metabolism | 8 | |
Carbohydrate metabolism | Galactose metabolism | 9 | |
Carbohydrate metabolism | Ascorbate and aldarate metabolism | 2 | |
Lipid metabolism | Fatty acid biosynthesis | 1 | |
Lipid metabolism | Fatty acid metabolism | 14 | |
Lipid metabolism | Synthesis and degradation of ketone bodies | 4 | |
Lipid metabolism | Steroid biosynthesis | 5 | |
Lipid metabolism | Primary bile acid biosynthesis | 5 | |
Metabolism of cofactors and vitamins | Ubiquinone and other terpenoid-quinone biosynthesis | 4 | |
Lipid metabolism | Steroid hormone biosynthesis | 7 | |
Energy metabolism | Oxidative phosphorylation | 31 | |
Nucleotide metabolism | Purine metabolism | 60 | |
Biosynthesis of other secondary metabolites | Caffeine metabolism | 1 | |
Nucleotide metabolism | Pyrimidine metabolism | 25 | |
Amino acid metabolism | Alanine, aspartate and glutamate metabolism | 9 | |
Amino acid metabolism | Glycine, serine and threonine metabolism | 8 | |
Amino acid metabolism | Cysteine and methionine metabolism | 10 | |
Amino acid metabolism | Valine, leucine and isoleucine degradation | 21 | |
Amino acid metabolism | Valine, leucine and isoleucine biosynthesis | 8 | |
Amino acid metabolism | Lysine biosynthesis | 3 | |
Amino acid metabolism | Lysine degradation | 24 | |
Amino acid metabolism | Arginine and proline metabolism | 16 | |
Amino acid metabolism | Histidine metabolism | 11 | |
Amino acid metabolism | Tyrosine metabolism | 9 | |
Amino acid metabolism | Phenylalanine metabolism | 2 | |
Amino acid metabolism | Tryptophan metabolism | 14 | |
Metabolism of other amino acids | beta-Alanine metabolism | 9 | |
Metabolism of other amino acids | Taurine and hypotaurine metabolism | 2 | |
Metabolism of other amino acids | Cyanoamino acid metabolism | 1 | |
Metabolism of other amino acids | D-Glutamine and D-glutamate metabolism | 1 | |
Metabolism of other amino acids | Glutathione metabolism | 11 | |
Carbohydrate metabolism | Starch and sucrose metabolism | 9 | |
Glycan biosynthesis and metabolism | N-Glycan biosynthesis | 19 | |
Glycan biosynthesis and metabolism | Other glycan degradation | 10 | |
Carbohydrate metabolism | Amino sugar and nucleotide sugar metabolism | 13 | |
Biosynthesis of other secondary metabolites | Butirosin and neomycin biosynthesis | 1 | |
Glycan biosynthesis and metabolism | Glycosaminoglycan degradation | 9 | |
Lipid metabolism | Glycerolipid metabolism | 16 | |
Carbohydrate metabolism | Inositol phosphate metabolism | 27 | |
Glycan biosynthesis and metabolism | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis | 13 | |
Lipid metabolism | Glycerophospholipid metabolism | 33 | |
Lipid metabolism | Ether lipid metabolism | 14 | |
Lipid metabolism | Arachidonic acid metabolism | 7 | |
Lipid metabolism | Linoleic acid metabolism | 3 | |
Lipid metabolism | alpha-Linolenic acid metabolism | 4 | |
Lipid metabolism | Sphingolipid metabolism | 23 | |
Glycan biosynthesis and metabolism | Glycosphingolipid biosynthesis - lacto and neolacto series | 8 | |
Glycan biosynthesis and metabolism | Glycosphingolipid biosynthesis - globo series | 3 | |
Glycan biosynthesis and metabolism | Glycosphingolipid biosynthesis - ganglio series | 9 | |
Carbohydrate metabolism | Pyruvate metabolism | 8 | |
Carbohydrate metabolism | Glyoxylate and dicarboxylate metabolism | 2 | |
Carbohydrate metabolism | Propanoate metabolism | 14 | |
Carbohydrate metabolism | Butanoate metabolism | 14 | |
Metabolism of cofactors and vitamins | One carbon pool by folate | 4 | |
Energy metabolism | Methane metabolism | 1 | |
Metabolism of cofactors and vitamins | Thiamine metabolism | 4 | |
Metabolism of cofactors and vitamins | Riboflavin metabolism | 5 | |
Metabolism of cofactors and vitamins | Nicotinate and nicotinamide metabolism | 9 | |
Metabolism of cofactors and vitamins | Pantothenate and CoA biosynthesis | 8 | |
Metabolism of cofactors and vitamins | Biotin metabolism | 1 | |
Metabolism of cofactors and vitamins | Lipoic acid metabolism | 1 | |
Metabolism of cofactors and vitamins | Folate biosynthesis | 7 | |
Metabolism of cofactors and vitamins | Retinol metabolism | 7 | |
Metabolism of cofactors and vitamins | Porphyrin and chlorophyll metabolism | 5 | |
Metabolism of terpenoids and polyketides | Terpenoid backbone biosynthesis | 4 | |
Metabolism of terpenoids and polyketides | Limonene and pinene degradation | 3 | |
Energy metabolism | Nitrogen metabolism | 7 | |
Energy metabolism | Sulfur metabolism | 5 | |
Xenobiotics biodegradation and metabolism | Metabolism of xenobiotics by cytochrome P450 | 10 | |
Xenobiotics biodegradation and metabolism | Drug metabolism - cytochrome P450 | 11 | |
Xenobiotics biodegradation and metabolism | Drug metabolism - other enzymes | 7 | |
Lipid metabolism | Biosynthesis of unsaturated fatty acids | 7 | |
Global and overview maps | Metabolic pathways | 350 |
Table: Organismal Systems | ||
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Pathway ID | Pathway Class | Description | Number of Genes with Somatic mutation |
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Endocrine system | PPAR signaling pathway | 22 | |
Immune system | Chemokine signaling pathway | 57 | |
Circulatory system | Cardiac muscle contraction | 22 | |
Circulatory system | Vascular smooth muscle contraction | 38 | |
Development | Dorso-ventral axis formation | 15 | |
Development | Axon guidance | 58 | |
Immune system | Complement and coagulation cascades | 16 | |
Immune system | Antigen processing and presentation | 25 | |
Endocrine system | Renin-angiotensin system | 4 | |
Immune system | Toll-like receptor signaling pathway | 38 | |
Immune system | NOD-like receptor signaling pathway | 20 | |
Immune system | RIG-I-like receptor signaling pathway | 28 | |
Immune system | Cytosolic DNA-sensing pathway | 14 | |
Immune system | Hematopoietic cell lineage | 22 | |
Immune system | Natural killer cell mediated cytotoxicity | 42 | |
Immune system | T cell receptor signaling pathway | 49 | |
Immune system | B cell receptor signaling pathway | 40 | |
Immune system | Fc epsilon RI signaling pathway | 32 | |
Immune system | Fc gamma R-mediated phagocytosis | 39 | |
Immune system | Leukocyte transendothelial migration | 36 | |
Immune system | Intestinal immune network for IgA production | 14 | |
Nervous system | Long-term potentiation | 31 | |
Nervous system | Neurotrophin signaling pathway | 53 | |
Nervous system | Long-term depression | 26 | |
Sensory system | Olfactory transduction | 17 | |
Sensory system | Taste transduction | 13 | |
Sensory system | Phototransduction | 3 | |
Endocrine system | Insulin signaling pathway | 59 | |
Endocrine system | GnRH signaling pathway | 49 | |
Endocrine system | Progesterone-mediated oocyte maturation | 37 | |
Endocrine system | Melanogenesis | 47 | |
Endocrine system | Adipocytokine signaling pathway | 21 | |
Excretory system | Aldosterone-regulated sodium reabsorption | 18 | |
Excretory system | Vasopressin-regulated water reabsorption | 16 | |
Excretory system | Proximal tubule bicarbonate reclamation | 6 | |
Excretory system | Collecting duct acid secretion | 6 |