SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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Browse biological pathways impacted by somatic mutations in miRNA target sites: Experimental

Target sites type:

Table: Cancer and other human diseases
 
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Pathway ID Pathway Class Description Number of Genes
with Somatic mutation
Cancers: Overview Pathways in cancer 158
Cancers: Specific types Colorectal cancer 33
Cancers: Specific types Renal cell carcinoma 33
Cancers: Specific types Pancreatic cancer 35
Cancers: Specific types Endometrial cancer 31
Cancers: Specific types Glioma 33
Cancers: Specific types Prostate cancer 45
Cancers: Specific types Thyroid cancer 11
Cancers: Specific types Basal cell carcinoma 29
Cancers: Specific types Melanoma 33
Cancers: Specific types Bladder cancer 20
Cancers: Specific types Chronic myeloid leukemia 37
Cancers: Specific types Acute myeloid leukemia 30
Cancers: Specific types Small cell lung cancer 45
Cancers: Specific types Non-small cell lung cancer 33
Cardiovascular diseases Hypertrophic cardiomyopathy (HCM) 33
Cardiovascular diseases Arrhythmogenic right ventricular cardiomyopathy (ARVC) 34
Cardiovascular diseases Viral myocarditis 29
Endocrine and metabolic diseases Type II diabetes mellitus 20
Endocrine and metabolic diseases Type I diabetes mellitus 16
Endocrine and metabolic diseases Maturity onset diabetes of the young 5
Immune diseases Asthma 8
Immune diseases Autoimmune thyroid disease 15
Immune diseases Systemic lupus erythematosus 65
Immune diseases Allograft rejection 13
Immune diseases Graft-versus-host disease 14
Immune diseases Primary immunodeficiency 11
Infectious diseases: Bacterial Bacterial invasion of epithelial cells 25
Infectious diseases: Bacterial Vibrio cholerae infection 14
Infectious diseases: Bacterial Epithelial cell signaling in Helicobacter pylori infection 19
Infectious diseases: Bacterial Pathogenic Escherichia coli infection 15
Infectious diseases: Bacterial Shigellosis 20
Infectious diseases: Parasitic Leishmaniasis 30
Neurodegenerative diseases Alzheimer's disease 50
Neurodegenerative diseases Parkinson's disease 35
Neurodegenerative diseases Amyotrophic lateral sclerosis (ALS) 22
Neurodegenerative diseases Huntington's disease 58
Neurodegenerative diseases Prion diseases 16


Table: Cellular Processes
 
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Pathway ID Pathway Class Description Number of Genes
with Somatic mutation
Cell growth and death Cell cycle 55
Cell growth and death Oocyte meiosis 43
Cell growth and death p53 signaling pathway 27
Transport and catabolism Regulation of autophagy 10
Transport and catabolism Lysosome 47
Transport and catabolism Endocytosis 88
Transport and catabolism Peroxisome 32
Cell growth and death Apoptosis 37
Cell communication Focal adhesion 78
Cell communication Adherens junction 34
Cell communication Tight junction 54
Cell communication Gap junction 41
Cell motility Regulation of actin cytoskeleton 75


Table: Environmental Information Processing
 
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Pathway ID Pathway Class Description Number of Genes
with Somatic mutation
Membrane transport ABC transporters 19
Signal transduction MAPK signaling pathway 112
Signal transduction ErbB signaling pathway 41
Signal transduction Calcium signaling pathway 59
Signaling molecules and interaction Cytokine-cytokine receptor interaction 68
Signal transduction Phosphatidylinositol signaling system 34
Signaling molecules and interaction Neuroactive ligand-receptor interaction 78
Signal transduction mTOR signaling pathway 21
Signal transduction Wnt signaling pathway 69
Signal transduction Notch signaling pathway 19
Signal transduction Hedgehog signaling pathway 29
Signal transduction TGF-beta signaling pathway 38
Signal transduction VEGF signaling pathway 31
Signaling molecules and interaction ECM-receptor interaction 32
Signaling molecules and interaction Cell adhesion molecules (CAMs) 42
Signal transduction Jak-STAT signaling pathway 41


Table: Genetic Information Processing
 
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Pathway ID Pathway Class Description Number of Genes
with Somatic mutation
Translation Aminoacyl-tRNA biosynthesis 16
Translation Ribosome 17
Folding, sorting and degradation RNA degradation 21
Transcription RNA polymerase 7
Transcription Basal transcription factors 13
Replication and repair DNA replication 7
Transcription Spliceosome 67
Folding, sorting and degradation Proteasome 16
Folding, sorting and degradation Protein export 8
Replication and repair Base excision repair 11
Replication and repair Nucleotide excision repair 11
Replication and repair Mismatch repair 6
Replication and repair Homologous recombination 8
Replication and repair Non-homologous end-joining 7
Folding, sorting and degradation Ubiquitin mediated proteolysis 58
Folding, sorting and degradation SNARE interactions in vesicular transport 16


Table: Metabolism
 
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Pathway ID Pathway Class Description Number of Genes
with Somatic mutation
Carbohydrate metabolism Glycolysis / Gluconeogenesis 15
Carbohydrate metabolism Citrate cycle (TCA cycle) 5
Carbohydrate metabolism Pentose phosphate pathway 8
Carbohydrate metabolism Pentose and glucuronate interconversions 2
Carbohydrate metabolism Fructose and mannose metabolism 8
Carbohydrate metabolism Galactose metabolism 9
Carbohydrate metabolism Ascorbate and aldarate metabolism 2
Lipid metabolism Fatty acid biosynthesis 1
Lipid metabolism Fatty acid metabolism 14
Lipid metabolism Synthesis and degradation of ketone bodies 4
Lipid metabolism Steroid biosynthesis 5
Lipid metabolism Primary bile acid biosynthesis 5
Metabolism of cofactors and vitamins Ubiquinone and other terpenoid-quinone biosynthesis 4
Lipid metabolism Steroid hormone biosynthesis 7
Energy metabolism Oxidative phosphorylation 31
Nucleotide metabolism Purine metabolism 60
Biosynthesis of other secondary metabolites Caffeine metabolism 1
Nucleotide metabolism Pyrimidine metabolism 25
Amino acid metabolism Alanine, aspartate and glutamate metabolism 9
Amino acid metabolism Glycine, serine and threonine metabolism 8
Amino acid metabolism Cysteine and methionine metabolism 10
Amino acid metabolism Valine, leucine and isoleucine degradation 21
Amino acid metabolism Valine, leucine and isoleucine biosynthesis 8
Amino acid metabolism Lysine biosynthesis 3
Amino acid metabolism Lysine degradation 24
Amino acid metabolism Arginine and proline metabolism 16
Amino acid metabolism Histidine metabolism 11
Amino acid metabolism Tyrosine metabolism 9
Amino acid metabolism Phenylalanine metabolism 2
Amino acid metabolism Tryptophan metabolism 14
Metabolism of other amino acids beta-Alanine metabolism 9
Metabolism of other amino acids Taurine and hypotaurine metabolism 2
Metabolism of other amino acids Cyanoamino acid metabolism 1
Metabolism of other amino acids D-Glutamine and D-glutamate metabolism 1
Metabolism of other amino acids Glutathione metabolism 11
Carbohydrate metabolism Starch and sucrose metabolism 9
Glycan biosynthesis and metabolism N-Glycan biosynthesis 19
Glycan biosynthesis and metabolism Other glycan degradation 10
Carbohydrate metabolism Amino sugar and nucleotide sugar metabolism 13
Biosynthesis of other secondary metabolites Butirosin and neomycin biosynthesis 1
Glycan biosynthesis and metabolism Glycosaminoglycan degradation 9
Lipid metabolism Glycerolipid metabolism 16
Carbohydrate metabolism Inositol phosphate metabolism 27
Glycan biosynthesis and metabolism Glycosylphosphatidylinositol(GPI)-anchor biosynthesis 13
Lipid metabolism Glycerophospholipid metabolism 33
Lipid metabolism Ether lipid metabolism 14
Lipid metabolism Arachidonic acid metabolism 7
Lipid metabolism Linoleic acid metabolism 3
Lipid metabolism alpha-Linolenic acid metabolism 4
Lipid metabolism Sphingolipid metabolism 23
Glycan biosynthesis and metabolism Glycosphingolipid biosynthesis - lacto and neolacto series 8
Glycan biosynthesis and metabolism Glycosphingolipid biosynthesis - globo series 3
Glycan biosynthesis and metabolism Glycosphingolipid biosynthesis - ganglio series 9
Carbohydrate metabolism Pyruvate metabolism 8
Carbohydrate metabolism Glyoxylate and dicarboxylate metabolism 2
Carbohydrate metabolism Propanoate metabolism 14
Carbohydrate metabolism Butanoate metabolism 14
Metabolism of cofactors and vitamins One carbon pool by folate 4
Energy metabolism Methane metabolism 1
Metabolism of cofactors and vitamins Thiamine metabolism 4
Metabolism of cofactors and vitamins Riboflavin metabolism 5
Metabolism of cofactors and vitamins Nicotinate and nicotinamide metabolism 9
Metabolism of cofactors and vitamins Pantothenate and CoA biosynthesis 8
Metabolism of cofactors and vitamins Biotin metabolism 1
Metabolism of cofactors and vitamins Lipoic acid metabolism 1
Metabolism of cofactors and vitamins Folate biosynthesis 7
Metabolism of cofactors and vitamins Retinol metabolism 7
Metabolism of cofactors and vitamins Porphyrin and chlorophyll metabolism 5
Metabolism of terpenoids and polyketides Terpenoid backbone biosynthesis 4
Metabolism of terpenoids and polyketides Limonene and pinene degradation 3
Energy metabolism Nitrogen metabolism 7
Energy metabolism Sulfur metabolism 5
Xenobiotics biodegradation and metabolism Metabolism of xenobiotics by cytochrome P450 10
Xenobiotics biodegradation and metabolism Drug metabolism - cytochrome P450 11
Xenobiotics biodegradation and metabolism Drug metabolism - other enzymes 7
Lipid metabolism Biosynthesis of unsaturated fatty acids 7
Global and overview maps Metabolic pathways 350


Table: Organismal Systems
 
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Pathway ID Pathway Class Description Number of Genes
with Somatic mutation
Endocrine system PPAR signaling pathway 22
Immune system Chemokine signaling pathway 57
Circulatory system Cardiac muscle contraction 22
Circulatory system Vascular smooth muscle contraction 38
Development Dorso-ventral axis formation 15
Development Axon guidance 58
Immune system Complement and coagulation cascades 16
Immune system Antigen processing and presentation 25
Endocrine system Renin-angiotensin system 4
Immune system Toll-like receptor signaling pathway 38
Immune system NOD-like receptor signaling pathway 20
Immune system RIG-I-like receptor signaling pathway 28
Immune system Cytosolic DNA-sensing pathway 14
Immune system Hematopoietic cell lineage 22
Immune system Natural killer cell mediated cytotoxicity 42
Immune system T cell receptor signaling pathway 49
Immune system B cell receptor signaling pathway 40
Immune system Fc epsilon RI signaling pathway 32
Immune system Fc gamma R-mediated phagocytosis 39
Immune system Leukocyte transendothelial migration 36
Immune system Intestinal immune network for IgA production 14
Nervous system Long-term potentiation 31
Nervous system Neurotrophin signaling pathway 53
Nervous system Long-term depression 26
Sensory system Olfactory transduction 17
Sensory system Taste transduction 13
Sensory system Phototransduction 3
Endocrine system Insulin signaling pathway 59
Endocrine system GnRH signaling pathway 49
Endocrine system Progesterone-mediated oocyte maturation 37
Endocrine system Melanogenesis 47
Endocrine system Adipocytokine signaling pathway 21
Excretory system Aldosterone-regulated sodium reabsorption 18
Excretory system Vasopressin-regulated water reabsorption 16
Excretory system Proximal tubule bicarbonate reclamation 6
Excretory system Collecting duct acid secretion 6